The artist has donated the complete sum of his £25,000 award prize money to the MVT, which works to protect the Britain's grassroots music venues.
He was awarded the cheque on mid-October as his latest record his work was declared the outstanding release of the previous year.
Fender has opted to hand the money over to the trust, in acknowledgment of the crucial part small stages fulfilled in his early career.
"As an artist would not have achieved this success if it hadn't been for all the gigs I played around the North East, and beyond, when I was beginning," stated the artist. "These locations are renowned, but they are facing challenges."
From early 2023 onward, more than 150 of these venues have shut down – about one-sixth of the entire UK sector.
In the last year, major artists like Pulp, Coldplay, Katy Perry and Sheeran have all aided the trust in its efforts to keep the scene afloat, by including a modest fee to their ticket costs, which goes to help smaller concert halls.
Sam Fender also took part, generating in excess of £100,000 on his live tour to assist 38 small stages across Britain.
These funds helped venues that were dealing with possible closure due to issues stemming from flooding, fires and family tragedies, as well as permit problems, court cases and sound issues.
Other venues were granted financial assistance in upgrading amenities and gear that helped artists and audiences.
"The notion that funds from shows in major spaces supports the smaller venues, where it all starts for artists like me, is just common sense," Sam Fender has stated.
Fender is far from the only musician to contribute his Mercury Prize funds to good deeds.
When the band earned the trophy in 1996 for their album Different Class, vocalist Jarvis Cocker announced that the act would give their cash to the charity War Child.
During 2002, rapper and singer Ms Dynamite shared her prize between a few good causes, like the NSPCC and a Sickle Cell organization.
"And I donated a thousand pounds to Highgate Newtown, to their classes, because I did gymnastics when I was younger and they lacked new equipment," she shared with the media.
In recent years, they contributed their prize money to the youth organization that nurtured their group, as well as other independent music bodies.
Additionally winners that year the group gave their winnings to a multiple sclerosis charity after a friend was found to have the illness.
"The victory was quite enough," stated artist the singer. "The cash was the extra but we could do without the cherry, because we had the main prize. So our success affected the lives of others."
Recently, the MVT revealed it had rescued a couple of local spots in that region, by bringing them into local control.
The Joiners in the city and the second in that location were acquired under the Own Our Venues initiative, which is backed by a national body and enthusiasts who purchase "ownership units" in the buildings.
