Fresh analysis indicates that people who come off blockbuster GLP-1 drugs like Wegovy and Mounjaro can put back on shed pounds much more quickly than those who stop conventional lifestyle plans.
Published data in a prominent health publication demonstrates that while obese individuals can lose substantial amounts of their body weight while on the medication, the weight returns at an estimated rate of 0.8 kg per month upon discontinuation.
"People buying such drugs must be aware of the risk of quick weight regain when the treatment ends," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to starting mass in about 18 months.
Comparing Treatments
The research, which reviewed dozens of studies involving thousands of participants, compared the effects of the injectable medications with conventional dieting.
Researchers emphasize that people who shed pounds through dieting usually experience a more gradual weight regain—approximately 100 grams monthly—post-intervention.
The Reason for the Quick Rebound
Doctors believe the mechanism of the injections is key to understanding the accelerated rebound.
These medications imitate a body's own chemical called GLP-1, which controls feelings of fullness.
"Long-term administration of GLP-1 concentrations several times higher than normal may cause the system to generate a reduced amount of its own natural hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement means hunger is no longer kept in check, making excessive eating much more probable."
A Chronic Disease?
Health authorities advise the jabs for individuals with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Many experts argue that, due to the significant potential of relapse, the therapy might need to be ongoing.
This view is reinforced by pharmaceutical companies, who note that the results "emphasize the persistent character of obesity," comparing it to managing diseases like high blood pressure.
User Testimonies
People who have come off the medication report a sudden return of cravings.
"It felt as if a trigger activating and I was suddenly extremely hungry," described one woman.
This difficulty is exacerbated if individuals have not adopted sustainable dietary or behavioural changes during treatment.
Widespread Adoption
Recent estimates show that a significant number of adults in the UK have tried weight-loss jabs in the past year, with interest being substantial.
- Adoption is greater among women compared to men.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than public health services.
Ultimately, researchers caution that while the jabs are potent tools for weight loss, they are not a magic solution and long-term success hinges on integrated lifestyle changes.
